Publication: A single dose‐response effect of aflatoxin B<inf>1</inf>on rapid liver cancer induction in two strains of rats
Issued Date
1990-01-01
Resource Type
ISSN
10970215
00207136
00207136
Other identifier(s)
2-s2.0-0025163020
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Cancer. Vol.46, No.4 (1990), 664-668
Suggested Citation
Subhkij Angsubhakorn, Panisa Get‐Ngern, Makoto Miyamoto, Natth Bhamarapravati A single dose‐response effect of aflatoxin B<inf>1</inf>on rapid liver cancer induction in two strains of rats. International Journal of Cancer. Vol.46, No.4 (1990), 664-668. doi:10.1002/ijc.2910460419 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15924
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A single dose‐response effect of aflatoxin B<inf>1</inf>on rapid liver cancer induction in two strains of rats
Other Contributor(s)
Abstract
To investigate rapid liver cancer induction in rats by aflatoxin B 1 (AFB 1 ), different single oral doses of AFB 1 were given to 3 groups of I‐year‐old Buffalo and Wistar rats. The animals were treated once and all survivors were killed 6 weeks later. Control animals received an equal volume of solvent (DMSO), and both groups of animals were maintained under identical conditions throughout the period of experiment. The survival rates were 40% with low and medium doses in AFB 1 ‐treated Buffalo and Wistar rats, and 0% in the high‐dose Buffalo rats. Slight ante‐mortem elevations in serum concentrations of glutamic pyruvic transaminase (SGOT) and glutamic oxaloacetic transaminase (SGPT) were indicative of the persistent damage effect of AFB 1 at week 6. Total protein and albumin concentrations were not altered. The percent incidence of altered cell foci (areas) and neoplastic nodules was higher in Wistar than in Buffalo rats given a similar low dose. Various stages of well differentiated hepatocellular carcinomas (0.1‐0.2 cm in diameter) developed in 3 of 8 Wistar rats. It thus appears that Wistar rats are more susceptible to hepatocarcinogenesis following a single oral dose of AFB 1 than Buffalo rats. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company