Publication: Human immune responses to melioidosis and cross-reactivity to low-virulence Burkholderia species, Thailand
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Issued Date
2020-01-01
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ISSN
10806059
10806040
10806040
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2-s2.0-85079917198
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Mahidol University
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SCOPUS
Bibliographic Citation
Emerging Infectious Diseases. Vol.26, No.3 (2020), 463-471
Suggested Citation
Patpong Rongkard, Barbara Kronsteiner, Viriya Hantrakun, Kemajittra Jenjaroen, Manutsanun Sumonwiriya, Panjaporn Chaichana, Suchintana Chumseng, Narisara Chantratita, Vanaporn Wuthiekanun, Helen A. Fletcher, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P.J. Day, Susanna J. Dunachie Human immune responses to melioidosis and cross-reactivity to low-virulence Burkholderia species, Thailand. Emerging Infectious Diseases. Vol.26, No.3 (2020), 463-471. doi:10.3201/eid2603.190206 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/54674
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Title
Human immune responses to melioidosis and cross-reactivity to low-virulence Burkholderia species, Thailand
Abstract
© 2020 Centers for Disease Control and Prevention (CDC). All rights reserved. Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. The causative agent is Burkholderia pseudomallei, a gram-negative soil-dwelling bacterium. In Thailand, B. pseudomallei can be found across multiple regions, along with the low-virulence B. thailandensis and the recently discovered B. thailandensis variant (BTCV), which expresses B. pseudomallei-like capsular polysaccharide. Comprehensive studies of human immune responses to B. thailandensis variants and cross-reactivity to B. pseudomallei are not complete. We evaluated human immune responses to B. pseudomallei, B. thailandensis, and BTCV in melioidosis patients and healthy persons in B. pseudomallei-endemic areas using a range of humoral and cellular immune assays. We found immune cross-reactivity to be strong for both humoral and cellular immunity among B. pseudomallei, B. thailandensis, and BTCV. Our findings suggest that environmental exposure to low-virulence strains may build cellular immunity to B. pseudomallei.