Publication: Performance of binaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects
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Issued Date
2015-01-01
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ISSN
00029637
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2-s2.0-84920557534
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.92, No.1 (2015), 22-27
Suggested Citation
Lyda Osorio, Nick Carter, Preetam Arthur, Germana Bancone, Sowmya Gopalan, Sandeep K. Gupta, Harald Noedl, Sanjay K. Kochar, Dhanpat K. Kochar, Srivicha Krudsood, Marcus V. Lacerda, Alejandro Llanos-Cuentas, Ronnatrai Rueangweerayut, Ramadurai Srinivasan, Moritz Treiber, Jörg J. Möhrle, Justin Green Performance of binaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects. American Journal of Tropical Medicine and Hygiene. Vol.92, No.1 (2015), 22-27. doi:10.4269/ajtmh.14-0298 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36181
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Title
Performance of binaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects
Other Contributor(s)
Universidad del Valle, Cali
GlaxoSmithKline plc.
Sri Ramachandra Medical College & Research Institute (Deemed University)
Shoklo Malaria Research Unit
MV Hospital and Research Centre
Medizinische Universitat Wien
Sardar Patel Medical College
University of Rajasthan
Mahidol University
Fundacao de Medicina Tropical do Amazonas
Universidad Peruana Cayetano Heredia
Mae Sot General Hospital
Clinical Development
GlaxoSmithKline plc.
Sri Ramachandra Medical College & Research Institute (Deemed University)
Shoklo Malaria Research Unit
MV Hospital and Research Centre
Medizinische Universitat Wien
Sardar Patel Medical College
University of Rajasthan
Mahidol University
Fundacao de Medicina Tropical do Amazonas
Universidad Peruana Cayetano Heredia
Mae Sot General Hospital
Clinical Development
Abstract
Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. The performance of the BinaxNOW G6PD test compared with the quantitative spectrophotometric analysis of G6PD activity was assessed in 356 Plasmodium vivax-infected subjects in Brazil, Peru, Thailand, and India. In the quantitative assay, the median G6PD activity was 8.81 U/g hemoglobin (range = 0.05-20.19), with 11 (3%) subjects identified as deficient. Sensitivity of the BinaxNOW G6PD to detect deficient subjects was 54.5% (6 of 11), and specificity was 100% (345 of 345). Room temperatures inadvertently falling outside the range required to perform the rapid test (18-25°C) together with subtlety of color change and insufficient training could partially explain the low sensitivity found. Ensuring safe use of 8-aminoquinolines depends on additional development of simple, highly sensitive G6PD deficiency diagnostic tests suitable for routine use in malaria-endemic areas.