Publication: Postprandial leptin response to Thai meals with different macronutrient mixtures
Issued Date
2006-07-01
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ISSN
01251562
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2-s2.0-33750204494
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.4 (2006), 778-783
Suggested Citation
Supornpim Chearskul, Thitiwan Yothathai, Sutin Sriussadaporn Postprandial leptin response to Thai meals with different macronutrient mixtures. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.37, No.4 (2006), 778-783. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/23705
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Title
Postprandial leptin response to Thai meals with different macronutrient mixtures
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Abstract
The objective of this study was to investigate the postprandial response of leptin, an appetite-regulating hormone, to different macronutrient mixtures in Thai meals. A within-subject repeat measurement was performed. Two groups of healthy Thais (10 men and 10 women in each group) received a single meal of equal calories composed either a high carbohydrate, low fat, low protein diet (HC-LFLP, carbohydrate:fat:protein = 70%:15%:15%) or a low carbohydrate, high fat, high protein diet (LC-HFHR carbohydrate:fat:protein = 20%:50%:30%). Fasting and 30-minute interval postprandial blood levels of leptin, insulin and glucose were measured for a 2-hour period. In comparison to the LC-HFHP meal, the HC-LFLP meal produced a greater increase in glucose and insulin levels, but halted leptin from decreasing. Postprandial leptin levels were suppressed by a LC-HFHP meal but not by a HC-LFLP meal. The reduced leptin in conjunction with lower glucose and insulin levels may encourage overeating in habitual LC-HFHP diet consumers.
