Publication: Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes
Issued Date
2004-07-01
Resource Type
ISSN
00664804
Other identifier(s)
2-s2.0-3042584838
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.48, No.7 (2004), 2751-2752
Suggested Citation
Mathieu Nacher, Udomsak Silachamroon, Pratap Singhasivanon, Polrat Wilairatana, Weerapong Phumratanaprapin, Arnaud Fontanet, Sornchai Looareesuwan Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes. Antimicrobial Agents and Chemotherapy. Vol.48, No.7 (2004), 2751-2752. doi:10.1128/AAC.48.7.2751-2752.2004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21616
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Title
Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes
Abstract
The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated patients (n = 792) than in chloroquine-treated patients (n = 695) (RR = 0.29; 95% CI = 0.2 to 0.40; P < 0.0001). The duration and magnitude of gametocyte carriage were also lower for artesunate than chloroquine. By reducing the transmission of Plasmodium vivax to the vector, artesunate could therefore reduce the incidence of P. vivax malaria.