Publication:
A modified Cu(0)-Cu(I)-mediated C<inf>aryl</inf>-C<inf>aryl</inf>Ullmann coupling for the synthesis of biaryls

Issued Date

2016-01-01

Resource Type

Article

ISSN

14645416
00404020

DOI

10.1016/j.tet.2016.07.063

Other identifier(s)

2-s2.0-84986286556

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Tetrahedron. Vol.72, No.40 (2016), 5994-6000

Suggested Citation

Kittisak Yasamut, Jira Jongcharoenkamol, Somsak Ruchirawat, Poonsakdi Ploypradith A modified Cu(0)-Cu(I)-mediated C<inf>aryl</inf>-C<inf>aryl</inf>Ullmann coupling for the synthesis of biaryls. Tetrahedron. Vol.72, No.40 (2016), 5994-6000. doi:10.1016/j.tet.2016.07.063 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/43319

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Title

A modified Cu(0)-Cu(I)-mediated C<inf>aryl</inf>-C<inf>aryl</inf>Ullmann coupling for the synthesis of biaryls

Author(s)

Kittisak Yasamut
 Jira Jongcharoenkamol
 Somsak Ruchirawat
 Poonsakdi Ploypradith

Other Contributor(s)

Chulabhorn Research Institute
 Mahidol University
 Chulabhorn Graduate Institute
 Thailand Ministry of Education

Abstract

© 2016 Elsevier Ltd A novel Cu(0)-Cu(I)-mediated Caryl-CarylUllmann coupling has been successfully developed. The use of Cu(I) salts allowed the reactions to proceed under relatively mild conditions (65 °C in DMSO for 15–72 h). The developed method was compatible with a relatively wide range of functional groups simultaneously present on the aromatic ring of different electronic nature. The aryl halides with an electron-withdrawing group ortho to the halide or an electron-donating group meta or para to the halide furnished the corresponding products in good to excellent yields (up to 98%).

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/43319

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Scopus 2016-2017