Publication: Deficit of female sex hormones desensitizes rat cardiac mitophagy
Issued Date
2021-03-01
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ISSN
26660059
03044920
03044920
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2-s2.0-85105472738
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Mahidol University
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SCOPUS
Bibliographic Citation
Chinese Journal of Physiology. Vol.64, No.2 (2021), 72-79
Suggested Citation
Theerachat Kampaengsri, Marisa Ponpuak, Jonggonnee Wattanapermpool, Tepmanas Bupha-Intr Deficit of female sex hormones desensitizes rat cardiac mitophagy. Chinese Journal of Physiology. Vol.64, No.2 (2021), 72-79. doi:10.4103/cjp.cjp_102_20 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76253
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Title
Deficit of female sex hormones desensitizes rat cardiac mitophagy
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Abstract
Long-term deprivation of female sex hormones has been shown to mediate accumulation of damaged mitochondria in ventricular muscle leading to cardiovascular dysfunction. Therefore, the roles of female sex hormones in mitochondrial quality control are closely focused. In the present study, depletion of female sex hormones impairing mitochondrial autophagy in the heart was hypothesized. Cardiac mitophagy was therefore investigated in the heart of 10-week ovariectomized (OVX) and sham-operated (SHAM) rats. By using isolated mitochondria preparation, results demonstrated an increase in mitochondrial PTEN-induced kinase 1 accumulation in the sample of OVX rats indicating mitochondrial outer membrane dysfunction. However, no change in p62 and LC3-II translocation to mitochondria was observed between two groups indicating unresponsiveness of mitophagosome formation in the OVX rat heart. This loss might be resulted from significant decreases in Parkin and Bcl2l13 expression, but not Bnip3 activation. In summary, results suggest that mitochondrial abnormality in the heart after deprivation of female sex hormones could consequently be due to desensitization of mitophagy process.