Publication: Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas
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Issued Date
2003-03-01
Resource Type
ISSN
02507005
Other identifier(s)
2-s2.0-0037862058
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Anticancer Research. Vol.23, No.2 C (2003), 1927-1931
Suggested Citation
Kulthida Vaeteewoottacharn, Patcharee Jearanaikoon, Mathurose Ponglikitmongkol Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas. Anticancer Research. Vol.23, No.2 C (2003), 1927-1931. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20757
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Title
Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas
Other Contributor(s)
Abstract
Infection with high-risk HPV16 is well associated with invasive cervical carcinomas. Variations in the E6 gene of HPV16 are shown to correlate with both the geographical areas and the oncogenicity. Here, we have characterized HPV16 DNA variants in the E6 and E7 coding regions of 31 Thai cervical squamous cell carcinomas. Five groups of E6 variants were identified. A mutation from T to G at nucleotide 178, leading to a change from aspartate to glutamate (D25E), was the most common variation accounting for 70%. Interestingly, 90% of these E6 (D25E) variants coincided with a specific type of E7 mutation, N29S. This is the first finding of coordinated change between E6 (D25E) and E7 (N29S) in HPV, which might indicate a specific variant for the Thai population. These comutations may not only represent an area-specific strain but may also be valuable for studying the virus and developing a suitable vaccine in Thailand.