Publication: Molecular investigation of carbapenem resistance among multidrug-resistant Pseudomonas aeruginosa isolated clinically in Thailand
| dc.contributor.author | Piyatip Khuntayaporn | en_US |
| dc.contributor.author | Preecha Montakantikul | en_US |
| dc.contributor.author | Pitak Santanirand | en_US |
| dc.contributor.author | Pattarachai Kiratisin | en_US |
| dc.contributor.author | Mullika Traidej Chomnawang | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-10-19T05:05:09Z | |
| dc.date.available | 2018-10-19T05:05:09Z | |
| dc.date.issued | 2013-03-01 | en_US |
| dc.description.abstract | Carbapenem resistant Pseudomonas aeruginosa were isolated among multidrug-resistant (CR-MDR) organisms from tertiary hospitals in Thailand. Decreased expression of oprD mRNA (93.65%) was predominant followed by increased expression of mexAB-oprM mRNA (92.06%) and mexXY mRNA (63.49%). Interestingly, 23 of 126 (18.25%) isolates were susceptible to imipenem with down-regulated oprD expression and non-up-regulated mexCD-oprJ mRNA expression. Metallo-β-lactamases production was clearly positive in 24 isolates (18.46%) and weakly positive in 12 isolates (9.23%). Among both of these sets of isolates, imp-1, imp-14 and vim-2 were identified. Hyperproduction of AmpC β-lactamase had the lowest prevalence rate (3.97%). It was concluded that CR-MDR P. aeruginosa clinical isolates in Thailand possess multifactorial resistance mechanisms. © 2012 The Societies and Wiley Publishing Asia Pty Ltd. | en_US |
| dc.identifier.citation | Microbiology and Immunology. Vol.57, No.3 (2013), 170-178 | en_US |
| dc.identifier.doi | 10.1111/1348-0421.12021 | en_US |
| dc.identifier.issn | 13480421 | en_US |
| dc.identifier.issn | 03855600 | en_US |
| dc.identifier.other | 2-s2.0-84875243491 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/31953 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875243491&origin=inward | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.title | Molecular investigation of carbapenem resistance among multidrug-resistant Pseudomonas aeruginosa isolated clinically in Thailand | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875243491&origin=inward | en_US |