Publication: Incidence and risk factors of corneal endothelial failure after phacoemulsification in patients with fuchs endothelial corneal dystrophy: A 13-year retrospective cohort
Issued Date
2021-01-01
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ISSN
11775483
11775467
11775467
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2-s2.0-85108146553
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Ophthalmology. Vol.15, (2021), 2367-2373
Suggested Citation
Varintorn Chuckpaiwong, Sasin Muakkul, Prae Phimpho, Kaevalin Lekhanont, Passara Jongkhajornpong Incidence and risk factors of corneal endothelial failure after phacoemulsification in patients with fuchs endothelial corneal dystrophy: A 13-year retrospective cohort. Clinical Ophthalmology. Vol.15, (2021), 2367-2373. doi:10.2147/OPTH.S315436 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78700
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Title
Incidence and risk factors of corneal endothelial failure after phacoemulsification in patients with fuchs endothelial corneal dystrophy: A 13-year retrospective cohort
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Abstract
Objective: To evaluate the incidence of corneal endothelial failure (CEF) and determine the risk factors of developing CEF after phacoemulsification in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: A retrospective chart review of 2873 patients who underwent phacoemulsification with intraocular lens (IOL) implantation was conducted at Ramathibodi Hospital, Bangkok, Thailand from January 2007 to December 2019. Patient baseline characteristics, underlying diseases, levels of nuclear cataract, pre-operative specular microscopic parameters, intraoperative information (cumulative dissipated energy [CDE], mode of phacoemulsification, and complications), and occurrence of CEF were collected. Data were analyzed using Kaplan- Meier (KM) method and Cox proportional hazard model. Results: Ninety-four patients diagnosed with FECD at follow-up time of more than 6 months were included for analysis. Mean age was 70.3 ± 7.7 years with female predominance (81.91%). Median follow-up time was 3.2 years. Nine (9.57%) patients developed CEF during follow-up period. The overall incidence rate of CEF after phacoemulsification was 26 per 1000 person years (95% confidence interval [CI]; 14 to 49 per 1000 person years). Only intraoperative complications showed significant association with CEF at hazard ratio (HR) of 6.03 (95% CI 1.50 to 26.50). No significant association was found among age, gender, underlying diseases, level of nuclear sclerosis and pre-operative specular microscopic parameters. Conclusion: Intraoperative complications should be considered as an important risk factor for developing post-operative CEF in FECD patients. Apart from assessing pre-operative parameters, surgeons should also consider the possibility of and try to avoid any intra- operative complications, which could potentially result in CEF after phacoemulsification for each individual patient.