Publication: Red cell quinine concentrations in falciparum malaria
1
Issued Date
1983-01-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-0020580843
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.32, No.3 (1983), 456-460
Suggested Citation
N. J. White, S. Looareesuwan, K. Silamut Red cell quinine concentrations in falciparum malaria. American Journal of Tropical Medicine and Hygiene. Vol.32, No.3 (1983), 456-460. doi:10.4269/ajtmh.1983.32.456 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30474
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Red cell quinine concentrations in falciparum malaria
Author(s)
Other Contributor(s)
Abstract
Red cell concentrations of quinine were measured in cerebral malaria and in uncomplicated falciparum malaria both in the acute stage and 1 month after recovery. Red cell quinine elimination half times were significantly shorter than the corresponding plasma half time in cerebral malaria and convalescent uncomplicated cases (P <0.001), but not in acute uncomplicated cases (P = 0.12). The ratio of red cell:plasma concentration fell progressively from the 2nd (0.49) to the 6th day (0.26) of treatment. On admission this ratio was positively correlated with the blood parasite count (P = 0.02). Red cell quinine concentration may be relevant to the assessment of drug resistance, and to the design of treatment regimens.