Publication: Red cell quinine concentrations in falciparum malaria
Issued Date
1983-01-01
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ISSN
00029637
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2-s2.0-0020580843
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.32, No.3 (1983), 456-460
Suggested Citation
N. J. White, S. Looareesuwan, K. Silamut Red cell quinine concentrations in falciparum malaria. American Journal of Tropical Medicine and Hygiene. Vol.32, No.3 (1983), 456-460. doi:10.4269/ajtmh.1983.32.456 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30474
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Title
Red cell quinine concentrations in falciparum malaria
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Abstract
Red cell concentrations of quinine were measured in cerebral malaria and in uncomplicated falciparum malaria both in the acute stage and 1 month after recovery. Red cell quinine elimination half times were significantly shorter than the corresponding plasma half time in cerebral malaria and convalescent uncomplicated cases (P <0.001), but not in acute uncomplicated cases (P = 0.12). The ratio of red cell:plasma concentration fell progressively from the 2nd (0.49) to the 6th day (0.26) of treatment. On admission this ratio was positively correlated with the blood parasite count (P = 0.02). Red cell quinine concentration may be relevant to the assessment of drug resistance, and to the design of treatment regimens.