Publication: 8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors
dc.contributor.author | Usanee Chatchotikawong | en_US |
dc.contributor.author | Irene Ruengkhachorn | en_US |
dc.contributor.author | Chairat Leelaphatanadit | en_US |
dc.contributor.author | Nisarat Phithakwatchara | en_US |
dc.contributor.other | Mahidol University | en_US |
dc.date.accessioned | 2018-11-23T09:48:18Z | |
dc.date.available | 2018-11-23T09:48:18Z | |
dc.date.issued | 2015-01-01 | en_US |
dc.description.abstract | Purpose: To determine the rate of lymph node metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumor (MOGCT). Materials and Methods: Medical records of apparent early-stage MOGCT patients undergoing primary surgical treatment at Siriraj Hospital, Bangkok, Thailand, between January 2006 and December 2013, were retrospectively reviewed. Results: Thirty-eight patients had apparent stage I-II MOGCT. The mean age was 22.1±7.7 years (median, 20.8 years; range, 7.7-35.6 years). The mean tumor size was 17.8±6.5 cm with a median of 20 (range 4-30) cm. Three most common histopathologies were dysgerminoma (12 patients, 31.6%), immature teratoma (12 patients, 31.6%), and endodermal sinus tumor (6 patients, 15.8%). Twenty-seven of 38 patients underwent lymphadenectomy; 13 patients (48.2%) were stage IA and 8 patients (29.6%) were stage IC. The rate of retroperitoneal nodes metastasis was 7.4% (2/27 patients). At 26.1 months of median follow-up time (range 1.9-88.5 months), 9 patients retained fertility functions, with uneventful pregnancies in 3 of these. Only one patient (2.6%) had progression of disease at 4.9 months after surgery. The 5-year survival rate was 97.4%. Conclusion: As the rate of pelvic or para-aortic node metastasis in MOGCT is considerable, lymphadenectomy should be incorporated in surgical staging procedures. | en_US |
dc.identifier.citation | Asian Pacific Journal of Cancer Prevention. Vol.16, No.4 (2015), 1609-1613 | en_US |
dc.identifier.doi | 10.7314/APJCP.2015.16.4.1609 | en_US |
dc.identifier.issn | 15137368 | en_US |
dc.identifier.other | 2-s2.0-84926227825 | en_US |
dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/35561 | |
dc.rights | Mahidol University | en_US |
dc.rights.holder | SCOPUS | en_US |
dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84926227825&origin=inward | en_US |
dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
dc.subject | Medicine | en_US |
dc.title | 8-year analysis of the prevalence of lymph nodes metastasis, oncologic and pregnancy outcomes in apparent early-stage malignant ovarian germ cell tumors | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84926227825&origin=inward | en_US |