Publication:
Morphological and microvascular changes of the adrenal glands in streptozotocin-induced long-term diabetic rats

dc.contributor.authorSirinush Sricharoenvejen_US
dc.contributor.authorSurasak Boonprasopen_US
dc.contributor.authorPassara Lanluaen_US
dc.contributor.authorSitha Piyawinijwongen_US
dc.contributor.authorApichaya Niyomchanen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-09-13T06:52:47Z
dc.date.available2018-09-13T06:52:47Z
dc.date.issued2009-10-19en_US
dc.description.abstractIt has been known that diabetes mellitus is associated with hyperfunction of the adrenal gland. However, the structural changes of adrenal gland in diabetes have rarely been studied. The aims of this study were to investigate the morphological and microvascular alterations in streptozotocin (STZ)-induced long-term diabetic rats. Twelve male Sprague-Dawley rats were divided into diabetic (n=8) and control (n=4) groups. Each diabetic rat was induced by an intraperitoneal injection of STZ (60 mg/kg) in citrate buffer (pH 4.5). Control rats were intraperitoneally injected with the same amounts of the buffer. These animals were sacrificed at 20 weeks after the injections. The adrenal glands were processed for the morphological and microvascular studies by using conventional light microscopy (LM) and vascular corrosion cast technique combined with scanning electron microscopy (SEM), respectively. In the diabetic group, the cells in zona glomeruloza (ZG) became atrophied and the thickness of this zone was found to be less than that of the controls. In the zona fasciculata (ZF) and zona reticularis (ZR), the hypertrophic cells were investigated in both layers. The degenerated chromaffin and hypertrophic sympathetic ganglion cells in the adrenal medulla were observed. Also some degenerated ganglion cells were found. Additionally, lymphocyte infiltration, macrophages and amyloidosis were found in the adrenal medulla of long-term diabetic rats with renal failure. Under the SEM observation, the luminal diameters of capillaries in the diabetic group were dilated in all zones. In addition, these capillaries in the ZF and ZR were arranged in tortuous courses. This study demonstrates morphological and microvascular changes in the adrenal gland of diabetic rats which are in accordance with the hormonal changes reported by previous investigators.en_US
dc.identifier.citationItalian Journal of Anatomy and Embryology. Vol.114, No.1 (2009), 1-10en_US
dc.identifier.issn11226714en_US
dc.identifier.other2-s2.0-70349897143en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/27888
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349897143&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleMorphological and microvascular changes of the adrenal glands in streptozotocin-induced long-term diabetic ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349897143&origin=inwarden_US

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