Publication: Predictive factors of axillary lymph node metastasis in breast cancer
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Issued Date
2011-01-01
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ISSN
01252208
01252208
01252208
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2-s2.0-79251570531
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.94, No.1 (2011), 65-70
Suggested Citation
Yodying Wasuthit, Youwanush Kongdan, Ronnarat Suvikapakornkul, Panuwat Lertsithichai, Prakasit Chirappapha Predictive factors of axillary lymph node metastasis in breast cancer. Journal of the Medical Association of Thailand. Vol.94, No.1 (2011), 65-70. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12708
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Title
Predictive factors of axillary lymph node metastasis in breast cancer
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Abstract
Objective: To identify clinical, radiologic and pathologic factors significantly related to axillary lymph node (ALN) metastasis in women with operable breast cancer. Material and Method: Records of women with operable invasive breast cancer treated between July 2002 and May 2006 were reviewed. Data on the number of axillary nodes, number of positive nodes, preoperative clinical, mammographic, and pathologic characteristics of each breast cancer were retrieved. Multiple logistic regression analyses were used to identify significant predictors of ALN metastasis. Results: Records of 590 patients were reviewed. Positive ALNs were found in 302 patients (51%). Independent and significant predictors of ALN metastasis included younger age, larger tumor size, presence of lymphovascular invasion, category 5 mammograms and low mammographic breast density. The combination of age less than 60 years, low mammographic breast density, category 5 mammogram, tumor larger 1 cm., and presence of lymphovascular invasion, had a specificity for predicting ALN metastasis of over 95%. Conclusion: A combination of clinical, radiologic, and pathologic characteristics highly specific for predicting ALN metastasis was found. This prediction rule might be useful for selecting breast cancer patients for full ALN dissection without a preliminary SLNB.