Publication: Selective delivery of doxorubicin using the biomarker-specific, aptamer-functionalized DNA nanosphere
Issued Date
2020-02-01
Resource Type
ISSN
18734979
0167577X
0167577X
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2-s2.0-85074633791
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Mahidol University
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SCOPUS
Bibliographic Citation
Materials Letters. Vol.260, (2020)
Suggested Citation
Supattra Chaithongyot, Ratchanee Duangrat, Chanida Wootthichairangsan, Rattanavinan Hanchaina, Anuttara Udomprasert, Thaned Kangsamaksin Selective delivery of doxorubicin using the biomarker-specific, aptamer-functionalized DNA nanosphere. Materials Letters. Vol.260, (2020). doi:10.1016/j.matlet.2019.126952 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/49601
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Title
Selective delivery of doxorubicin using the biomarker-specific, aptamer-functionalized DNA nanosphere
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Abstract
© 2019 Elsevier B.V. Targeted drug delivery systems have attracted much attention as they can enhance treatment efficiency and minimize cytotoxicity of chemotherapeutic drugs. Several nanomaterials with biological advantages have been explored for novel drug carrier invention. Here, a DNA origami nanosphere modified with a specific aptamer was developed for selective doxorubicin delivery. The specificity of the targeted nanocarrier was investigated against three cell lines with different levels of Mucin 1 (MUC1) expression. Our data showed that the doxorubicin-loaded, MUC1 aptamer-functionalized nanosphere (Dox-Apt-sphere) preferentially delivered drugs and exhibited cytotoxic effects at low Dox concentration in MUC1-high MCF-7 cells. These results also proved that the aptamer-modified DNA nanostructure may serve as a promising candidate for targeted drug delivery.