Publication:
Non-mutagenic and genotoxic effects of water extract of piper sarmentosum using ames and micronucleus assay

dc.contributor.authorAchiraya Tammasakchaien_US
dc.contributor.authorPenchom Peungvichaen_US
dc.contributor.authorRungravi Temsiririrkkulen_US
dc.contributor.authorPongpun Siripongen_US
dc.contributor.authorPranom Puchadapiromen_US
dc.contributor.otherNational Cancer Institute Thailanden_US
dc.contributor.otherNaresuan Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2022-08-04T11:42:00Z
dc.date.available2022-08-04T11:42:00Z
dc.date.issued2021-01-01en_US
dc.description.abstractP. sarmentosum possesses a variety of biological activities and has long been used as a food ingredient and traditional medicine to treat many diseases. In this study, its mutagenic and genotoxic activities on S. typhimurium TA98 and TA100 and fibroblast (V79) cells were examined. Mediated by S9 activation, the water extract of P. sarmentosum at a high dose caused the number of revertant colonies to increase in the tester strains TA98 (20 mg/plate) and TA100 (40 mg/plate), but there was no mutagenic effect in the presence of S9 in mixed condition. The extract (1-7.5 mg/ml) showed no significant genotoxic effect based on the frequency of micronucleus formation both with and without S9 in mixed conditions. In conclusion, the water extract of P. sarmentosum has neither direct nor indirect genotoxic effects and has no mutagenic effects indirectly. Therefore, the results indicate that P. sarmentosum is safe for use as a food supplement.en_US
dc.identifier.citationSongklanakarin Journal of Science and Technology. Vol.43, No.1 (2021), 203-209en_US
dc.identifier.issn01253395en_US
dc.identifier.other2-s2.0-85103257938en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/79403
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103257938&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleNon-mutagenic and genotoxic effects of water extract of piper sarmentosum using ames and micronucleus assayen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103257938&origin=inwarden_US

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