Publication: Butein, isoliquiritigenin, and scopoletin attenuate neurodegenerationviaantioxidant enzymes and SIRT1/ADAM10 signaling pathway
Issued Date
2020-04-27
Resource Type
ISSN
20462069
Other identifier(s)
2-s2.0-85084312106
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
RSC Advances. Vol.10, No.28 (2020), 16593-16606
Suggested Citation
Naw Hser Gay, Wilasinee Suwanjang, Waralee Ruankham, Napat Songtawee, Prapimpun Wongchitrat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin Butein, isoliquiritigenin, and scopoletin attenuate neurodegenerationviaantioxidant enzymes and SIRT1/ADAM10 signaling pathway. RSC Advances. Vol.10, No.28 (2020), 16593-16606. doi:10.1039/c9ra06056a Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/56150
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Butein, isoliquiritigenin, and scopoletin attenuate neurodegenerationviaantioxidant enzymes and SIRT1/ADAM10 signaling pathway
Other Contributor(s)
Abstract
© The Royal Society of Chemistry 2020. Neuronal cell death is a key feature of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Plant polyphenols, namely butein, isoliquiritigenin, and scopoletin, have been shown to exhibit various biological activities including anti-inflammatory, antimicrobial, and antioxidant activities. Herein, butein, isoliquiritigenin, and scopoletin were explored for their neuroprotective properties against oxidative stress-induced human dopaminergic SH-SY5Y cell death. The cells exposed to hydrogen peroxide (H2O2) revealed a reduction in cell viability and increases in apoptosis and levels of reactive oxygen species (ROS). Interestingly, pretreatment of SH-SY5Y cells with 5 µM of butein, isoliquiritigenin, or scopoletin protected against the cell death induced by H2O2, and decreased the levels of apoptotic cells and ROS. In addition, the levels of SIRT1, FoxO3a, ADAM10, BCL-2, and antioxidant enzymes (catalase and SOD2) were maintained in the cells pretreated with butein, isoliquiritigenin, or scopoletin before H2O2treatment compared to cells without pretreatment and the reference (resveratrol). Molecular docking analysis revealed that the interactions between the activator-binding sites of SIRT1 and the phenolic compounds were similar to those of resveratrol. Taken together, the data suggest that these polyphenolic compounds could be potential candidates for prevention and/or treatment of neurodegeneration.