Publication: Immunoreactivity of a 38-Kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera
Issued Date
1997-09-01
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ISSN
00951137
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2-s2.0-0030804032
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Microbiology. Vol.35, No.9 (1997), 2220-2223
Suggested Citation
P. Chongtrakool, S. C. Chaiyaroj, V. Vithayasai, S. Trawatcharegon, R. Teanpaisan, S. Kalnawakul, S. Sirisinha Immunoreactivity of a 38-Kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera. Journal of Clinical Microbiology. Vol.35, No.9 (1997), 2220-2223. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17965
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Title
Immunoreactivity of a 38-Kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera
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Abstract
Penicillium marneffei produced and secreted a 38-kDa antigen that appeared to be specific for this dimorphic fungus. This component could not be detected in antigenic extracts of Histoplasma capsulatum, Cryptococcus neoformans, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Candida albicans, and two other species of Penicillium by immunoblot analysis against the sera from patients with culture-confirmed penicilliosis marneffei. Antibody reactive with this antigen was found in a large proportion of human immunodeficiency virus (HIV)-positive patients, indicating a presumptive diagnosis of P. marneffei infection. A small number of asymptomatic HIV-seropositive patients and HIV-seropositive patients with other fungal infections were also found to be positive by this analysis, suggesting that subclinical or mixed fungal infections involving P. marneffei are not uncommon.