Publication: Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease
Issued Date
2012-03-01
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ISSN
18750834
17602734
17602734
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2-s2.0-84858449938
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Veterinary Cardiology. Vol.14, No.1 (2012), 269-279
Suggested Citation
Melanie J. Hezzell, Adrian Boswood, Walasinee Moonarmart, Jonathan Elliott Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease. Journal of Veterinary Cardiology. Vol.14, No.1 (2012), 269-279. doi:10.1016/j.jvc.2012.01.009 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13782
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Title
Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease
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Abstract
Objectives: To determine if echocardiographic measurements change at a greater rate in dogs with myxomatous mitral valve disease (MMVD) that die of cardiac mortality. Animals: Client-owned dogs (n = 242) with MMVD of varying severity were recruited from first opinion private practice. Only dogs which died during the study period (n = 102) were included in statistical analyses. Methods: Prospective cohort study comparing the rate of change of echocardiographic variables between dogs that experienced cardiac mortality and those that experienced non-cardiac mortality. Measurements were repeated approximately every 6 months and repeated measures linear models were constructed to estimate the rate of change of each variable over time. Results: Left ventricular (LV) end-diastolic diameter, normalized for body weight (LVEDDN) increased over time in both mortality groups. LV end-systolic diameter, normalized for body weight (LVESDN), LV end-diastolic diameter to LV free wall thickness in diastole (LVEDD/LVFWd) ratio, E wave velocity, E- to A-wave velocity ratio and left atrial to aortic root diameter ratio all increased over time in the cardiac mortality group, but did not change in the non-cardiac mortality group. MR velocity decreased over time in the cardiac mortality group but did not change in the non-cardiac mortality group. Tricuspid regurgitation jet velocity increased over time in both mortality groups. A wave velocity and fractional shortening did not change over time in either mortality group. Conclusions: Serial echocardiographic examination every 6-12 months is useful to identify dogs with progressive MMVD that are at increased risk of cardiac mortality. © 2012 Elsevier B.V. All rights reserved.