Publication: Clastogenic effect of aqueous extracts of palmyrah (Borassus flabellifer) flour on human blood lymphocytes
Issued Date
1981-01-01
Resource Type
ISSN
01651218
Other identifier(s)
2-s2.0-0019463272
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Mutation Research/Genetic Toxicology. Vol.89, No.1 (1981), 63-68
Suggested Citation
Daoroong Kangwanpong, S. N. Arseculeratne, S. Sirisinha Clastogenic effect of aqueous extracts of palmyrah (Borassus flabellifer) flour on human blood lymphocytes. Mutation Research/Genetic Toxicology. Vol.89, No.1 (1981), 63-68. doi:10.1016/0165-1218(81)90131-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30161
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Clastogenic effect of aqueous extracts of palmyrah (Borassus flabellifer) flour on human blood lymphocytes
Other Contributor(s)
Abstract
Palmyrah (Borassus flabellifer) flour is consumed by humans in some Asian and African countries. In view of its toxic and carcinogenic effects, including the induction of malignant lymphomas in rats, we examined the mutagenic effects of aqueous extracts of the flour on human blood lymphocytes in vitro. The extracts were clastogenic, mainly to group A chromosomes, producing chromatid and chromosome gaps, and chromatid and chromosome breaks with some formation of large and small acentric fragments. Dicentric chromosomes and chromatid interchanges were rare. No ring chromosome was detected. These effects were dose-dependent and were consistently produced by crude extracts of different batches of flour, but were less frequent than the clastogenic effects of mitomycin C which was used as a positive control. No mitogenic effect of the extracts alone was observed. © 1981.