Publication: Serum neuropeptide Y and leptin levels compared between non-pregnant and pregnant women in overall, non-obese, and obese subjects
Issued Date
2018-05-01
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ISSN
22288082
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2-s2.0-85051598657
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Mahidol University
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SCOPUS
Bibliographic Citation
Siriraj Medical Journal. Vol.70, No.3 (2018), 204-212
Suggested Citation
Chantacha Sitticharoon, Roongrit Klinjampa, Xaynaly Souvannavong-Vilivong, Saimai Chatree, Peerada Boonpuan, Chanakarn Sripong, Nay Chi Nway, Tripop Lertbunnaphong Serum neuropeptide Y and leptin levels compared between non-pregnant and pregnant women in overall, non-obese, and obese subjects. Siriraj Medical Journal. Vol.70, No.3 (2018), 204-212. doi:10.14456/smj.2018.34 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46718
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Title
Serum neuropeptide Y and leptin levels compared between non-pregnant and pregnant women in overall, non-obese, and obese subjects
Abstract
© 2018, Faculty of Medicine Siriraj Hospital, Mahidol University. Objective: The primary objective of this study was to compare serum NPY and leptin levels between non-pregnant and pregnant women in overall, non-obese, and obese subjects. The secondary objective was to compare these peptides between non-obese and obese pregnant women. Methods: Fasting venous blood was collected from non-pregnant women before open abdominal surgery and from pregnant women when admitted to the delivery room during the latent phase of labor. Results: There were 12 non-obese and 14 obese subjects in the non-pregnant group and 9 non-obese and 30 obese subjects in the pregnant group. Systolic blood pressure (SBP) was comparable, but heart rate (HR) was higher in pregnant compared to non-pregnant women. Mean±S.E.M serum NPY levels were lower in the pregnant than in the non-pregnant group in overall (0.54±0.02 and 1.34±0.08, respectively), non-obese (0.53±0.05 and 1.23±0.14, respectively), and obese (0.54±0.03 and 1.43±0.09, respectively) subjects (p<0.01 for all), but these were comparable between obese and nonobese pregnant subjects. Serum NPY was positively correlated with SBP (R=0.281, p<0.05), but negatively correlated with HR (R=-0.324, p<0.01). Serum leptin levels were not different between pregnant and non-pregnant groups, but were significantly higher in obese than non-obese pregnant subjects (p<0.001). Serum leptin levels were positively correlated with body weight, BMI, waist and hip circumferences in overall and pregnant subjects (p<0.001 all). Conclusion: In pregnancy, decreased NPY levels might be associated with inhibition of SBP rising as well as increased HR. Leptin levels might not be associated with pregnancy, but associated mainly with obesity.