Publication:
Application of the hypervalent iodine reagent to the synthesis of some pentasubstituted aporphine alkaloids

Issued Date

2007-09-17

Resource Type

Article

ISSN

09365214

DOI

10.1055/s-2007-985596

Other identifier(s)

2-s2.0-34948839846

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Synlett. No.15 (2007), 2363-2366

Suggested Citation

Ratchanok Pingaew, Somsak Ruchirawat Application of the hypervalent iodine reagent to the synthesis of some pentasubstituted aporphine alkaloids. Synlett. No.15 (2007), 2363-2366. doi:10.1055/s-2007-985596 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24337

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Title

Application of the hypervalent iodine reagent to the synthesis of some pentasubstituted aporphine alkaloids

Author(s)

Ratchanok Pingaew
 Somsak Ruchirawat

Other Contributor(s)

Mahidol University
 Chulabhorn Research Institute
 The Institute of Science and Technology for Research and Development, Mahidol University

Abstract

The oxidative biaryl coupling of various N-substituted 1- benzyltetrahydroisoquinolines to the corresponding aporphines by the hypervalent iodine reagent was studied. The study sheds light on the unifying mechanism of the reaction illustrating the requirement of the p-p coupling via the six-membered transition state as the initial step. The finding was applied to the synthesis of some pentasubstituted aporphine alkaloids. © Georg Thieme Verlag Stuttgart.

Keyword(s)

Chemistry

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URI

https://repository.li.mahidol.ac.th/handle/123456789/24337

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Scopus 2006-2010