Publication: MDR1 C3435T and C1236T polymorphisms: Association with high-risk childhood acute lymphoblastic leukemia
Issued Date
2015-01-01
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ISSN
15137368
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2-s2.0-84928606170
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.16, No.7 (2015), 2839-2843
Suggested Citation
Wanida Pongstaporn, Samart Pakakasama, Panee Chaksangchaichote, Tanett Pongtheerat, Suradej Hongeng, Songsak Permitr MDR1 C3435T and C1236T polymorphisms: Association with high-risk childhood acute lymphoblastic leukemia. Asian Pacific Journal of Cancer Prevention. Vol.16, No.7 (2015), 2839-2843. doi:10.7314/APJCP.2015.16.7.2839 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35612
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Title
MDR1 C3435T and C1236T polymorphisms: Association with high-risk childhood acute lymphoblastic leukemia
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Abstract
Background: MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood. Materials and Methods: To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with the occurrence and outcome of ALL, 208 children with ALL (median age 5.0 yr) and 101 healthy Thai children were studied by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) assay. Results: C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR= 2.6, 95%CI =1.164-5.808; P =0.028 and OR= 2.231, 95%CI =1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.