Publication: Electrophysiological and immunological study in myasthenia gravis: Diagnostic sensitivity and correlation
Issued Date
2011-09-01
Resource Type
ISSN
18728952
13882457
13882457
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2-s2.0-79960889595
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Neurophysiology. Vol.122, No.9 (2011), 1873-1877
Suggested Citation
Rawiphan Witoonpanich, Charungthai Dejthevaporn, Arporn Sriphrapradang, Teeratorn Pulkes Electrophysiological and immunological study in myasthenia gravis: Diagnostic sensitivity and correlation. Clinical Neurophysiology. Vol.122, No.9 (2011), 1873-1877. doi:10.1016/j.clinph.2011.02.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12345
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Title
Electrophysiological and immunological study in myasthenia gravis: Diagnostic sensitivity and correlation
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Abstract
Objective: To determine the diagnostic sensitivity of repetitive nerve stimulation (RNS), single fiber electromyography (SFEMG) and acetylcholine receptor antibody (AChRAb) in myasthenia gravis (MG), and to compare the degree of SFEMG abnormality between ocular and generalized MG and between seronegative and seropositive patients. Methods: The sensitivities of RNS, SFEMG and AChRAb were estimated. SFEMG abnormality was compared between ocular and generalized MG and between seronegative and seropositive patients. Results: Abnormal RNS, abnormal SFEMG and AChRAb were detected in 62%, 93% and 38% of 42 ocular, and 80%, 99% and 73% of 70 generalized cases, respectively. The degree of SFEMG abnormality was significantly greater in the generalized than ocular patients and was significantly greater in the seropositive than seronegative patients in both extensor digitorum communis and orbicularis oculi muscles. Conclusion: SFEMG is a very sensitive and useful test for MG. A correlation between SFEMG abnormality and clinical phenotype or severity and between SFEMG abnormality and AChRAb seropositivity was demonstrated. Significance: The sensitivities of RNS, SFEMG and AChRAb in the diagnosis of MG were documented. The differences in severity between the ocular and generalized MG and between the seronegative and seropositive MG were confirmed and quantitatively determined by SFEMG. © 2011 International Federation of Clinical Neurophysiology.