Publication: The WorldWide Antimalarial Resistance Network Clinical Trials Publication Library: A Live, Open-Access Database of Plasmodium Treatment Efficacy Trials
Issued Date
2020-07-01
Resource Type
ISSN
14761645
Other identifier(s)
2-s2.0-85088203826
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The American journal of tropical medicine and hygiene. Vol.103, No.1 (2020), 359-368
Suggested Citation
Junko Takata, Paul Sondo, Georgina S. Humphreys, Rebekah Burrow, Brittany Maguire, Mohammad S. Hossain, Debashish Das, Robert J. Commons, Ric N. Price, Philippe J. Guerin The WorldWide Antimalarial Resistance Network Clinical Trials Publication Library: A Live, Open-Access Database of Plasmodium Treatment Efficacy Trials. The American journal of tropical medicine and hygiene. Vol.103, No.1 (2020), 359-368. doi:10.4269/ajtmh.19-0706 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/57958
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The WorldWide Antimalarial Resistance Network Clinical Trials Publication Library: A Live, Open-Access Database of Plasmodium Treatment Efficacy Trials
Other Contributor(s)
Menzies School of Health Research
Mahidol University
International Centre for Diarrhoeal Disease Research Bangladesh
Nuffield Department of Medicine
Infectious Diseases Data Observatory (IDDO)
Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN)
WorldWide Antimalarial Resistance Network (WWARN)
Mahidol University
International Centre for Diarrhoeal Disease Research Bangladesh
Nuffield Department of Medicine
Infectious Diseases Data Observatory (IDDO)
Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN)
WorldWide Antimalarial Resistance Network (WWARN)
Abstract
Parasite resistance to antimalarial drugs poses a serious threat to malaria control. The WorldWide Antimalarial Resistance Network (WWARN) aims to provide a collaborative platform to support the global malaria research effort. Here, we describe the "WWARN clinical trials publication library," an open-access, up-to-date resource to streamline the synthesis of antimalarial safety and efficacy data. A series of iteratively refined database searches were conducted to identify prospective clinical trials assessing antimalarial drug efficacy with at least 28 days of follow-up. Of approximately 45,000 articles screened, 1,221 trials published between 1946 and 2018 were identified, representing 2,339 treatment arms and 323,819 patients. In trials from endemic locations, 75.7% (787/1,040) recruited patients with Plasmodium falciparum, 17.0% (177/1,040) Plasmodium vivax, 6.9% (72/1,040) both, and 0.4% (4/1,040) other Plasmodium species; 57.2% (585/1,022) of trials included under-fives and 5.3% (55/1,036) included pregnant women. In Africa, there has been a marked increase in both P. falciparum and P. vivax studies over the last two decades. The WHO-recommended artemisinin-based combination therapies alone or with a gametocidal drug were assessed in 39.5% (705/1,783) of P. falciparum treatment arms and 10.5% (45/429) of P. vivax arms, increasing to 78.0% (266/341) and 22.9% (27/118), respectively, in the last five years. The library is a comprehensive, open-access tool that can be used by the malaria community to explore the collective knowledge on antimalarial efficacy (available at https://www.wwarn.org/tools-resources/literature-reviews/wwarn-clinical-trials-publication-library). It is the first of its kind in the field of global infectious diseases, and lessons learnt in its creation can be adapted to other infectious diseases.