Publication:
Depsides and depsidones from the soil-derived fungus Aspergillus unguis PSU-RSPG204

Simple item page
dc.contributor.authorPatima Phainuphongen_US
dc.contributor.authorVatcharin Rukachaisirikulen_US
dc.contributor.authorSouwalak Phongpaichiten_US
dc.contributor.authorJariya Sakayarojen_US
dc.contributor.authorPhongthon Kanjanasiriraten_US
dc.contributor.authorSuparerk Borwornpinyoen_US
dc.contributor.authorNattaphong Akrimajirachooteen_US
dc.contributor.authorChantapol Yimnualen_US
dc.contributor.authorChatchai Muanprasaten_US
dc.contributor.otherWalailak Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.date.accessioned2019-08-23T10:28:08Z
dc.date.available2019-08-23T10:28:08Z
dc.date.issued2018-09-27en_US
dc.description.abstract© 2018 Elsevier Ltd Three new depsides, aspergisides A-C, and one new depsidone, aspergisidone, were isolated from the soil-derived fungus Aspergillus unguis PSU-RSPG204 together with one phthalide derivative and 11 depsidones including emeguisin A, aspersidone and folipastatin. The structures were determined by spectroscopic evidence. Aspersidone and emeguisin A showed remarkably antibacterial activity against Staphylococcus aureus and methicillin-resistance S. aureus with equal MIC values of 0.5 μg/mL. Emeguisin A, which displayed the highest activity with 87.06% inhibition of human colon carcinoma (HCT-116) cell viability, decreased numbers of live cells/numbers of dead cells in a dose-dependent manner with the IC50 values of 34.8–84.7 μM in a 3D culture model depending on durations of incubation. In addition, folipastatin dose-dependently inhibited forskolin-stimulated chloride secretion in human intestinal epithelial (T84) cells with an IC50 value of 0.5 μM. These depsidones were considered to be inactive against noncancerous Vero Cells with the IC50 values of >10 μM.en_US
dc.identifier.citationTetrahedron. Vol.74, No.39 (2018), 5691-5699en_US
dc.identifier.doi10.1016/j.tet.2018.07.059en_US
dc.identifier.issn14645416en_US
dc.identifier.issn00404020en_US
dc.identifier.other2-s2.0-85051529528en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/45049
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051529528&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDepsides and depsidones from the soil-derived fungus Aspergillus unguis PSU-RSPG204en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051529528&origin=inwarden_US

Files

Collections

Scopus 2018