Publication:
Mutations of the FLT3 gene in adult acute myeloid leukemia: Determination of incidence and identification of a novel mutation in a Thai population

dc.contributor.authorChirayu U. Auewarakulen_US
dc.contributor.authorNarongrit Sritanaen_US
dc.contributor.authorChanin Limwongseen_US
dc.contributor.authorWanna Thongnoppakhunen_US
dc.contributor.authorPa Thai Yenchitsomanusen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-06-21T08:07:59Z
dc.date.available2018-06-21T08:07:59Z
dc.date.issued2005-10-15en_US
dc.description.abstractFLT3 mutations have been reported to be the most frequent mutation in acute myeloid leukemia (AML). No data currently exist regarding FLT3 mutations in Southeast Asian patients. In this study, the incidence and type of FLT3 mutation in a large series of Thai AML patients were determined. FLT3 internal tandem duplication (ITD) mutations were observed in 24.6%, FLT3 tyrosine kinase domain mutations in 3.1%, and dual mutations in 2.7% of 256 newly diagnosed Thai AML patients. ITD mutations were mostly restricted to the juxtamembrane domain, and the in-frame ITD length varied from 21 to 201 base pairs. Six types of point mutations were identified, including Asp835Tyr, Asp835His, Asp835Glu, Asp835Ala, Ile836, and a novel mutation, Asp835Del/Ile836Val, which resulted in the loss of aspartic acid and substitution of isoleucine by valine. A rare leukemia karyotype, trisomy 11, was found to coexist with this novel FLT3 mutation, whereas the majority of patients with FLT3 mutations had a normal karyotype. Overall, FLT3 mutation was associated with a significantly higher white blood cell count and older age than the wild-type FLT3. In conclusion, the incidence of FLT3 mutation in Thailand is as high as that of western countries. The clinical significance of the novel mutation requires further studies in a larger population. © 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationCancer Genetics and Cytogenetics. Vol.162, No.2 (2005), 127-134en_US
dc.identifier.doi10.1016/j.cancergencyto.2005.03.011en_US
dc.identifier.issn01654608en_US
dc.identifier.other2-s2.0-26444458755en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/16285
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26444458755&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleMutations of the FLT3 gene in adult acute myeloid leukemia: Determination of incidence and identification of a novel mutation in a Thai populationen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26444458755&origin=inwarden_US

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