Publication: Allogeneic stem cell transplantation in a patient with refractory Burkitt's lymphoma using non-myeloablative conditioning regimen
Issued Date
2000-12-01
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ISSN
02683369
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2-s2.0-0034486239
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Mahidol University
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SCOPUS
Bibliographic Citation
Bone Marrow Transplantation. Vol.26, No.12 (2000), 1351-1354
Suggested Citation
A. Ungkanont, W. Mongkonsritrakoon, S. Jootar, T. Srichaikul Allogeneic stem cell transplantation in a patient with refractory Burkitt's lymphoma using non-myeloablative conditioning regimen. Bone Marrow Transplantation. Vol.26, No.12 (2000), 1351-1354. doi:10.1038/sj.bmt.1702730 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26094
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Title
Allogeneic stem cell transplantation in a patient with refractory Burkitt's lymphoma using non-myeloablative conditioning regimen
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Abstract
We have performed an allogeneic stem cell transplant in an 18-year-old male patient who had Burkitt's lymphoma. The patient had disease which was refractory to conventional intensive chemotherapy and radiation therapy. High-dose chemotherapy with autologous stem cell rescue was given but the patient relapsed within 2 months after transplantation. He was then treated with allogeneic stem cell transplantation using a fludarabine, busulfan and anti-thymocyte globulin-based conditioning regimen. His GVHD prophylaxis included mycophenolate and tacrolimus. The patient had engraftment within 14 days. Investigation by FISH showed more than 95% of his peripheral blood nucleated cells to be of donor origin since day +14. He is now alive and well and remains disease-free 6-months after the transplant. A graft-versus-lymphoma effect is thought to be one of the factors contributing to his remission.