Publication: Gastrointestinal bleeding among hospitalizations for salicylate poisoning in the United States
Issued Date
2021-03-01
Resource Type
ISSN
14602393
14602725
14602725
Other identifier(s)
2-s2.0-85107087233
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Mahidol University
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SCOPUS
Bibliographic Citation
QJM. Vol.114, No.3 (2021), 190-195
Suggested Citation
C. Thongprayoon, K. Lapumnuaypol, W. Kaewput, T. Petnak, F. Qureshi, M. A. Mao, B. Boonpheng, T. Bathini, A. Choudhury, S. Vallabhajosyula, W. Cheungpasitporn Gastrointestinal bleeding among hospitalizations for salicylate poisoning in the United States. QJM. Vol.114, No.3 (2021), 190-195. doi:10.1093/qjmed/hcab034 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78361
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Title
Gastrointestinal bleeding among hospitalizations for salicylate poisoning in the United States
Other Contributor(s)
Stevens Institute of Technology
MedStar Georgetown University Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
The University of Arizona
Phramongkutklao College of Medicine
Mayo Clinic
David Geffen School of Medicine at UCLA
Emory University School of Medicine
Mayo Clinic in Jacksonville, Florida
MedStar Georgetown University Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
The University of Arizona
Phramongkutklao College of Medicine
Mayo Clinic
David Geffen School of Medicine at UCLA
Emory University School of Medicine
Mayo Clinic in Jacksonville, Florida
Abstract
Background: This study aimed to determine the incidence, as well as evaluate risk factors, and impact of gastrointestinal bleeding on outcomes and resource use in patients admitted for salicylate poisoning. Methods: We used the National Inpatient Sample to construct a cohort of patients hospitalized primarily for salicylate poisoning from 2003 to 2014. We compared clinical characteristics, in-hospital treatments, outcomes and resource use between salicylate poisoning patients with and without gastrointestinal bleeding. Results: Of 13 805 hospital admissions for salicylate poisoning, gastrointestinal bleeding occurred in 482 (3.5%) admissions. The risk factors for gastrointestinal bleeding included older age, history of atrial fibrillation and cirrhosis. After adjusting for difference in baseline characteristics, patients with gastrointestinal bleeding required more gastric lavage, gastrointestinal endoscopy, invasive mechanical ventilation and red blood cell transfusion. Gastrointestinal bleeding was significantly associated with increased risk of anemia, circulatory, liver and hematological failure but was not significantly associated with increased in-hospital mortality. The length of hospital stay and hospitalization cost was significantly higher in patients with gastrointestinal bleeding. Conclusion: Gastrointestinal bleeding occurred in about 4% of patients admitted for salicylate poisoning. Gastrointestinal bleeding was associated with higher morbidity and resource use but not mortality.