Publication: The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology
Issued Date
2020-01-01
Resource Type
ISSN
13989995
01054538
01054538
Other identifier(s)
2-s2.0-85082525975
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Mahidol University
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SCOPUS
Bibliographic Citation
Allergy: European Journal of Allergy and Clinical Immunology. (2020)
Suggested Citation
Sathish Paramasivan, Ahmed Bassiouni, Arron Shiffer, Matthew R. Dillon, Emily K. Cope, Clare Cooksley, Mahnaz Ramezanpour, Sophia Moraitis, Mohammad Javed Ali, Benjamin Bleier, Claudio Callejas, Marjolein E. Cornet, Richard G. Douglas, Daniel Dutra, Christos Georgalas, Richard J. Harvey, Peter H. Hwang, Amber U. Luong, Rodney J. Schlosser, Pongsakorn Tantilipikorn, Marc A. Tewfik, Sarah Vreugde, Peter John Wormald, J. Gregory Caporaso, Alkis J. Psaltis The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology. Allergy: European Journal of Allergy and Clinical Immunology. (2020). doi:10.1111/all.14276 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54586
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Title
The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology
Author(s)
Sathish Paramasivan
Ahmed Bassiouni
Arron Shiffer
Matthew R. Dillon
Emily K. Cope
Clare Cooksley
Mahnaz Ramezanpour
Sophia Moraitis
Mohammad Javed Ali
Benjamin Bleier
Claudio Callejas
Marjolein E. Cornet
Richard G. Douglas
Daniel Dutra
Christos Georgalas
Richard J. Harvey
Peter H. Hwang
Amber U. Luong
Rodney J. Schlosser
Pongsakorn Tantilipikorn
Marc A. Tewfik
Sarah Vreugde
Peter John Wormald
J. Gregory Caporaso
Alkis J. Psaltis
Ahmed Bassiouni
Arron Shiffer
Matthew R. Dillon
Emily K. Cope
Clare Cooksley
Mahnaz Ramezanpour
Sophia Moraitis
Mohammad Javed Ali
Benjamin Bleier
Claudio Callejas
Marjolein E. Cornet
Richard G. Douglas
Daniel Dutra
Christos Georgalas
Richard J. Harvey
Peter H. Hwang
Amber U. Luong
Rodney J. Schlosser
Pongsakorn Tantilipikorn
Marc A. Tewfik
Sarah Vreugde
Peter John Wormald
J. Gregory Caporaso
Alkis J. Psaltis
Other Contributor(s)
Pontificia Universidad Católica de Chile
University of New South Wales (UNSW) Australia
Northern Arizona University
Medical University of South Carolina
Macquarie University
The University of Texas at Austin
Stanford University
Faculty of Medicine, Siriraj Hospital, Mahidol University
The University of Adelaide
Universidade de Sao Paulo - USP
University of Auckland
Harvard Medical School
McGill University
Amsterdam UMC
LV Prasad Institute
University of New South Wales (UNSW) Australia
Northern Arizona University
Medical University of South Carolina
Macquarie University
The University of Texas at Austin
Stanford University
Faculty of Medicine, Siriraj Hospital, Mahidol University
The University of Adelaide
Universidade de Sao Paulo - USP
University of Auckland
Harvard Medical School
McGill University
Amsterdam UMC
LV Prasad Institute
Abstract
© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. The sinonasal microbiome remains poorly defined, with our current knowledge based on a few cohort studies whose findings are inconsistent. Furthermore, the variability of the sinus microbiome across geographical divides remains unexplored. We characterize the sinonasal microbiome and its geographical variations in both health and disease using 16S rRNA gene sequencing of 410 individuals from across the world. Although the sinus microbial ecology is highly variable between individuals, we identify a core microbiome comprised of Corynebacterium, Staphylococcus, Streptococcus, Haemophilus and Moraxella species in both healthy and chronic rhinosinusitis (CRS) cohorts. Corynebacterium (mean relative abundance = 44.02%) and Staphylococcus (mean relative abundance = 27.34%) appear particularly dominant in the majority of patients sampled. Amongst patients suffering from CRS with nasal polyps, a statistically significant reduction in relative abundance of Corynebacterium (40.29% vs 50.43%; P =.02) was identified. Despite some measured differences in microbiome composition and diversity between some of the participating centres in our cohort, these differences would not alter the general pattern of core organisms described. Nevertheless, atypical or unusual organisms reported in short-read amplicon sequencing studies and that are not part of the core microbiome should be interpreted with caution. The delineation of the sinonasal microbiome and standardized methodology described within our study will enable further characterization and translational application of the sinus microbiota.