Publication: Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes
Issued Date
2005-02-01
Resource Type
ISSN
01252208
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2-s2.0-20444477912
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.88, No.2 (2005), 233-237
Suggested Citation
Jitra Waikagul, Dorn Watthanakulpanich, Chatree Muennoo, Wanna Maipanich, Surapol Sa-Nguankiat, Somchit Phubampen Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes. Journal of the Medical Association of Thailand. Vol.88, No.2 (2005), 233-237. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17066
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Title
Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes
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Abstract
The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed. At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.