Publication: Interaction of antimalarial drugs with hemin
Issued Date
1983-01-01
Resource Type
ISSN
15734935
01448463
01448463
Other identifier(s)
2-s2.0-0020973717
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Mahidol University
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SCOPUS
Bibliographic Citation
Bioscience Reports. Vol.3, No.12 (1983), 1113-1117
Suggested Citation
B. Panijpan, Ch Mohan Rao, D. Balasubramanian Interaction of antimalarial drugs with hemin. Bioscience Reports. Vol.3, No.12 (1983), 1113-1117. doi:10.1007/BF01120204 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30450
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Title
Interaction of antimalarial drugs with hemin
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Abstract
Hemin (ferriprotoporphyrin IX) is shown to form complexes with the chloroquine class of antimalarial drugs. The Soret band of hemin becomes optically active upon the addition of chiral drugs. Results on the hemin-induced quenching of the fluorescence of chloroquine are consistent with the formation of a 2:1 hemin:drug complex with a formation constant of 1.4×10<sup>7</sup> at 298 K. Also a direct comparison of the drug-treated and drug-free parasites themselves, by the noninvasive photoacoustic spectroscopic method, reveals an in vivo interaction between endogenous hemin and the added drug. © 1983 The Biochemical Society.
