Publication: Four novel phenanthrene derivatives with α-glucosidase inhibitory activity from gastrochilus bellinus
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Issued Date
2021-01-02
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14203049
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2-s2.0-85100328006
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.26, No.2 (2021)
Suggested Citation
Htoo Tint San, Nutputsorn Chatsumpun, Thaweesak Juengwatanatrakul, Natapol Pornputtapong, Kittisak Likhitwitayawuid, Boonchoo Sritularak Four novel phenanthrene derivatives with α-glucosidase inhibitory activity from gastrochilus bellinus. Molecules. Vol.26, No.2 (2021). doi:10.3390/molecules26020418 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76308
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Title
Four novel phenanthrene derivatives with α-glucosidase inhibitory activity from gastrochilus bellinus
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Abstract
Four new phenanthrene derivatives, gastrobellinols A-D (1–4), were isolated from the methanolic extract of Gastrochilus bellinus (Rchb.f.) Kuntze, along with eleven known phenolic compounds including agrostophyllin (5), agrostophyllidin (6), coniferyl aldehyde (7), 4-hydroxybenzaldehyde (8), agrostophyllone (9), gigantol (10), 4-(methoxylmethyl)phenol (11), syringaldehyde (12), 1-(4′-hydroxybenzyl)-imbricartin (13), 6-methoxycoelonin (14), and imbricatin (15). Their structures were determined by spectroscopic methods. Each isolate was evaluated for α-glucosidase inhibitory activity. Compounds 1, 2, 3, 7, 9, 13, and 15 showed higher activity than the drug acarbose. Gastrobellinol C (3) exhibited the strongest α-glucosidase inhibition with an IC50 value of 45.92 µM. A kinetic study of 3 showed competitive inhibition on the α-glucosidase enzyme. This is the first report on the phytochemical constituents and α-glucosidase inhibitory activity of G. bellinus.