Publication:
In vivo parasitological measures of artemisinin susceptibility

Issued Date

2010-02-15

Resource Type

Article

ISSN

00221899

DOI

10.1086/650301

Other identifier(s)

2-s2.0-75749087199

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Infectious Diseases. Vol.201, No.4 (2010), 570-579

Suggested Citation

Kasia Stepniewska, Elizabeth Ashley, Sue J. Lee, Nicholas Anstey, Karen I. Barnes, Tran Quang Binh, Umberto D'Alessandro, Nicholas P.J. Day, Peter J. De Vries, Grant Dorsey, Jean Paul Guthmann, Mayfong Mayxay, Paul N. Newton, Piero Olliaro, Lyda Osorio, Rie N. Price, Mark Rowland, Frank Smithuis, Walter R.J. Taylor, François Nosten, Nicholas J. White In vivo parasitological measures of artemisinin susceptibility. Journal of Infectious Diseases. Vol.201, No.4 (2010), 570-579. doi:10.1086/650301 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29769

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Title

In vivo parasitological measures of artemisinin susceptibility

Author(s)

Kasia Stepniewska
 Elizabeth Ashley
 Sue J. Lee
 Nicholas Anstey
 Karen I. Barnes
 Tran Quang Binh
 Umberto D'Alessandro
 Nicholas P.J. Day
 Peter J. De Vries
 Grant Dorsey
 Jean Paul Guthmann
 Mayfong Mayxay
 Paul N. Newton
 Piero Olliaro
 Lyda Osorio
 Rie N. Price
 Mark Rowland
 Frank Smithuis
 Walter R.J. Taylor
 François Nosten
 Nicholas J. White

Other Contributor(s)

Mahidol University
 Shoklo Malaria Research Unit
 Menzies School of Health Research
 University of Cape Town
 Cho Ray Hospital
 Prins Leopold Instituut voor Tropische Geneeskunde
 University of Oxford
 London School of Hygiene & Tropical Medicine
 Academic Medical Centre, University of Amsterdam
 University of California, San Francisco
 Institut de Recherche en Sciences de la Santé
 Uganda Malaria Surveillance Program
 Epicentre
 Institut de Veille Sanitaire
 National University of Laos
 Oxford University Tropical Medicine Research Collaboration
 Organisation Mondiale de la Sante
 Hopitaux universitaires de Geneve
 Centra Internacional de Entrenamiento e Investigaciones Medicas
 Imperial College Healthcare NHS Trust

Abstract

Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n = 14,539), moderate (n = 2077), and high (n = 2083) levels of malaria transmission across the world were analyzed to determine the factors that affect clearance rates and identify a simple in vivo screening measure for artemisinin resistance. The main factor affecting parasite clearance time was parasite density on admission. Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs). The result of the malaria blood smear on day 3 (72 h) was a good predictor of subsequent treatment failure and provides a simple screening measure for artemisinin resistance. Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites//μL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%; that is, for n patients the observed number with a positive smear result on day 3 does not exceed (n + 60)/24. © 2010 by the Infectious Diseases Society of America. All rights reserved.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/29769

Collections

Scopus 2006-2010