Publication: Antiherpetic effects of Gynura procumbens
Issued Date
2013-10-18
Resource Type
ISSN
17414288
1741427X
1741427X
Other identifier(s)
2-s2.0-84885448375
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Mahidol University
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SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013)
Suggested Citation
Siripen Jarikasem, Somyot Charuwichitratana, Sontana Siritantikorn, Wasan Chantratita, Magdy Iskander, August Wilhelm Frahm, Weena Jiratchariyakul Antiherpetic effects of Gynura procumbens. Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013). doi:10.1155/2013/394865 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32111
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Title
Antiherpetic effects of Gynura procumbens
Abstract
The ethanol extract of Gynura procumbens showed virucidal and antireplicative actions against herpes simplex virus HSV-1 and HSV-2. It was further chromatographed on MCI gel CHP20P column giving the extract fractions F1 (water), F2 (water-methanol) F3 (methanol), and F4 (ethyl acetate). All but F1 had virucidal action against both viral types. We reported here the active compounds from F2 and F3. The antiherpetic compounds of F2 was a mixture of dicaffeoylquinic acids with virucidal and antireplicative actions against HSV-2 (IC96.0 and 61.0 g/mL, resp.) Virucidal compounds of F3 were a mixture of β-sitosterol and stigmasterol (IC250.0 g/mL against HSV-1), a mixture of β-sitosteryl and stigmasteryl glucosides (IC50.0 g/mL against HSV-2) and 1, 2-bis-dodecanoyl-3-α-D-glucopyranosyl-sn-glycerol (ICof 40.0 g/mL against HSV-2). Herbal products containing 1 and 2% of standardized ethanol extract were prepared. Double-blind randomized controlled clinical trial of the products was performed in patients with recurrent herpes labialis. Results showed that the number of patients, whose lesions healed within 7 days and the average healing time of both groups differed insignificantly. Viral culture on D7 indicated a decrease of infected patients from 48.7% to 7.69% in treated group whereas in placebo group the infected patients decreased from 31.25% to 20.00%. The viral reduction in treated group indicated the benefit of the product. Insignificant result might arise from a low number of participated patients and insufficient concentration of plant extract in herbal product. © 2013 Siripen Jarikasem et al.