Publication: A new source of whitening agent from a Thai Mulberry plant and its betulinic acid quantitation
Issued Date
2008-06-15
Resource Type
ISSN
14786427
14786419
14786419
Other identifier(s)
2-s2.0-46749101449
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research. Vol.22, No.9 (2008), 727-734
Suggested Citation
Snitmatjaro Nattapong, Luanratana Omboon A new source of whitening agent from a Thai Mulberry plant and its betulinic acid quantitation. Natural Product Research. Vol.22, No.9 (2008), 727-734. doi:10.1080/14786410601130794 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18726
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Title
A new source of whitening agent from a Thai Mulberry plant and its betulinic acid quantitation
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Abstract
Protection of human body against the harmful ultraviolet exposure is nowadays more important and interesting. Melanin, a group of bio-pigments, acts as a natural solar filter absorbing and reflecting most of the UV radiation passing through the layer of skin. Over production of the pigments can create a health problem, hyperpigmentation. Tyrosinase is a key enzyme, which catalyzes the conversion of L-tyrosine to L-dihydroxyalanine (L-Dopa), therefore tyrosinase inhibitors are used in various skin preparations due to its pronounced effect on anti-hyperpigment. In this study, an in vitro anti-tyrosinase activity study of the extracts from a hybrid Mulberry plant obtained from Morus alba L. and Morus rotundiloba Koidz, is shown to prove as new source of Thai whitening agent. The presence of betulinic acid, as an anti-inflammatory and anti-tyrosinase activity agent, is also reported. The study develops the technique of HPLC quantitation of betulinic acid and its relation to anti-tyrosinase activity of the whole parts of Thai Mulberry.