Publication: Nondeletional Hb Queens Park [α32(B13)Met→Lys]/Hb H (β4) disease
Issued Date
2012-06-01
Resource Type
ISSN
1532432X
03630269
03630269
Other identifier(s)
2-s2.0-84860786091
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Hemoglobin. Vol.36, No.3 (2012), 293-298
Suggested Citation
Suravee Sroymora, Sumalee Jindadamrongwech, Punnee Butthep, Suporn Chuncharunee Nondeletional Hb Queens Park [α32(B13)Met→Lys]/Hb H (β4) disease. Hemoglobin. Vol.36, No.3 (2012), 293-298. doi:10.3109/03630269.2012.658939 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13709
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Title
Nondeletional Hb Queens Park [α32(B13)Met→Lys]/Hb H (β4) disease
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Abstract
A rare nondeletional α-thalassemia-2 (α-thal-2) allele was identified in a Thai boy with Hb H (β4) disease. The proband has α-thal-1 (- SEA type) together with a non productive Hb Queens Park (HBA1:c.98T > A) [α32(B13)Met→Lys] α1-globin variant. No abnormal hemoglobin (Hb) fraction was detected by high performance liquid chromatography (HPLC). The clinical effect of this mutation in the proband was comparable to that of deletional α-thal-2 present in Hb H disease. Copyright © Informa Healthcare USA, Inc.