Publication: Synthesis and theoretical study of molecularly imprinted nanospheres for recognition of tocopherols
Issued Date
2009-08-01
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ISSN
14203049
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2-s2.0-69549137897
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Mahidol University
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SCOPUS
Bibliographic Citation
Molecules. Vol.14, No.8 (2009), 2985-3002
Suggested Citation
Theeraphon Piacham, Chanin Nantasenamat, Thummaruk Suksrichavalit, Charoenchai Puttipanyalears, Tippawan Pissawong, Supanee Maneewas, Chartchalerm Isarankura-Na-Ayudhya, Virapong Prachayasittikul Synthesis and theoretical study of molecularly imprinted nanospheres for recognition of tocopherols. Molecules. Vol.14, No.8 (2009), 2985-3002. doi:10.3390/molecules14082985 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27404
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Title
Synthesis and theoretical study of molecularly imprinted nanospheres for recognition of tocopherols
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Abstract
Molecular imprinting is a technology that facilitates the production of artificial receptors toward compounds of interest. The molecularly imprinted polymers act as artificial antibodies, artificial receptors, or artificial enzymes with the added benefit over their biological counterparts of being highly durable. In this study, we prepared molecularly imprinted polymers for the purpose of binding specifically to tocopherol (vitamin E) and its derivative, tocopherol acetate. Binding of the imprinted polymers to the template was found to be two times greater than that of the control, non-imprinted polymers, when using only 10 mg of polymers. Optimization of the rebinding solvent indicated that ethanol-water at a molar ratio of 6:4 (v/v) was the best solvent system as it enhanced the rebinding performance of the imprinted polymers toward both tocopherol and tocopherol acetate with a binding capacity of approximately 2 mg/g of polymer. Furthermore, imprinted nanospheres against tocopherol was successfully prepared by precipitation polymerization with ethanol-water at a molar ratio of 8:2 (v/v) as the optimal rebinding solvent. Computer simulation was also performed to provide mechanistic insights on the binding mode of template-monomer complexes. Such polymers show high potential for industrial and medical applications, particularly for selective separation of tocopherol and derivatives. © 2009.