Publication: Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?
Issued Date
2021-09-01
Resource Type
ISSN
14714159
00223042
00223042
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2-s2.0-85109086970
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Neurochemistry. Vol.158, No.6 (2021), 1292-1306
Suggested Citation
Kornraviya Sankorrakul, Lei Qian, Wipawan Thangnipon, Elizabeth J. Coulson Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?. Journal of Neurochemistry. Vol.158, No.6 (2021), 1292-1306. doi:10.1111/jnc.15451 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76061
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Title
Is there a role for the p75 neurotrophin receptor in mediating degeneration during oxidative stress and after hypoxia?
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Abstract
Cholinergic basal forebrain (cBF) neurons are particularly vulnerable to degeneration following trauma and in neurodegenerative conditions. One reason for this is their characteristic expression of the p75 neurotrophin receptor (p75NTR), which is up-regulated and mediates neuronal death in a range of neurological and neurodegenerative conditions, including dementia, stroke and ischaemia. The signalling pathway by which p75NTR signals cell death is incompletely characterised, but typically involves activation by neurotrophic ligands and signalling through c-Jun kinase, resulting in caspase activation via mitochondrial apoptotic signalling pathways. Less well appreciated is the link between conditions of oxidative stress and p75NTR death signalling. Here, we review the literature describing what is currently known regarding p75NTR death signalling in environments of oxidative stress and hypoxia to highlight the overlap in signalling pathways and the implications for p75NTR signalling in cBF neurons. We propose that there is a causal relationship and define key questions to test this assertion. (Figure presented.).