Publication: 3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus
Issued Date
2010-10-29
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ISSN
15701808
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2-s2.0-77958499309
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Mahidol University
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SCOPUS
Bibliographic Citation
Letters in Drug Design and Discovery. Vol.7, No.9 (2010), 674-678
Suggested Citation
Ratana Lawung, Lertyot Treeratanapiboon, Supaluk Prachayasittikul, Virapong Prachayasittikul 3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus. Letters in Drug Design and Discovery. Vol.7, No.9 (2010), 674-678. doi:10.2174/157018010792929603 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28612
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Title
3-(1-adamantylthio)-4-phenylpyridine as a potential therapeutic for methicillin-resistant staphylococcus aureus
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Abstract
In a previous study, 5-(1-adamantylthio)-3-picoline (I) and 3-(1-adamantylthio)-4-phenylpyridine (II) were shown to have potent antimicrobial activity. The present investigation is concerned with the antimicrobial action of thiopyridines I and II against methicillin-resistant Staphylococcus aureus (MRSA) isolates and with their murine fibroblast (L929) cytotoxicity. Thiopyridine II was found to display significant antimicrobial activity against all of the MRSA isolates tested, with minimum inhibitory concentrations (MIC) of 1-8 μg/mL. Moreover, both I and II attenuate the viability of L929 cells in a dose-dependent manner, displaying an IC50 of 68.4±6.0 and 47.3±5.6 μg/mL, respectively. These findings suggest that thiopyridine II is promising as a lead compound for further development as a therapeutic. © 2010 Bentham Science Publishers Ltd.