Publication: Predicting factors for unsuccessful switching from nevirapine to efavirenz in HIV-infected patients who developed nevirapine-associated skin rash
Issued Date
2009-03-01
Resource Type
ISSN
09564624
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2-s2.0-62249161449
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of STD and AIDS. Vol.20, No.3 (2009), 176-179
Suggested Citation
S. Kiertiburanakul, K. Malathum, S. Watcharananan, B. Sathapatayavongs, S. Sungkanuparph Predicting factors for unsuccessful switching from nevirapine to efavirenz in HIV-infected patients who developed nevirapine-associated skin rash. International Journal of STD and AIDS. Vol.20, No.3 (2009), 176-179. doi:10.1258/ijsa.2008.008231 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28145
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Title
Predicting factors for unsuccessful switching from nevirapine to efavirenz in HIV-infected patients who developed nevirapine-associated skin rash
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Abstract
Summary: Skin rash associated with nevirapine (NVP) is common and efavirenz (EFV) is often used as a substitute. We aimed to determine the predicting factors for unsuccessful switching from NVP to EFV. A retrospective cohort study was conducted in HIV-infected patients who developed rash after taking NVP. There were 109 patients with a mean standard deviation (SD) age of 36.6 (7.4) years and 45% were males. Median (interquartile range) CD4 cell count and HIV RNA at the time of NVP initiation were 163 (50-273) cells/mm3and 4.6 (1.7-5.4) log copies/mL, respectively. Twenty (18.3%) patients subsequently developed EFV-associated rash. By logistic regression, history of drug allergy apart from NVP (odds ratio [OR] 11.42) and CD4 cell count,100 cells/mm3(OR 6.14) were significant predicting factors for EFV-associated rash. Two predicting factors for unsuccessful switching from NVP to EFV were found. Patients who have these factors need to have a close follow-up if EFV is substituted.