Publication: Distribution of killer cell Immunoglobulin-like receptor genes in Thai blood donors
Issued Date
2011-06-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-79957698623
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.94, No.6 (2011), 738-742
Suggested Citation
Chutima Tammakorn, Tasanee Mongkolsuk, Duangtawan Thammanichanond, Samart Pakakasama, Pimpun Kitpoka Distribution of killer cell Immunoglobulin-like receptor genes in Thai blood donors. Journal of the Medical Association of Thailand. Vol.94, No.6 (2011), 738-742. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12474
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Title
Distribution of killer cell Immunoglobulin-like receptor genes in Thai blood donors
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Abstract
Background: Killer cell Immunoglobulin-like Receptors (KIRs) are members of a group of molecules expressed on the surfaces of natural killer (NK) cells and some T cells. KIRs recognize MHC class I molecules on target cells. The interaction of these molecules regulates NK cell reactivity. The KIR gene cluster is highly polymorphic in individuals and different populations. Objective: Determine the frequencies and diversities of KIR genes among the Thai population. Results: Seventeen KIR genes and common subtypes were identified in 500 healthy Thai blood donors by PCR-SSP. The framework genes KIR2DL4, KIR3DL2, KIR3DL3, and KIR3DP1 were present in all individuals (100%). The observed frequencies of KIR genes vary in the presented population. The most frequent non-framework KIR gene was KIR2DL1 (98.4%) while the least frequent was KIR2DL5B (24.2%). Conclusion: It was observed that the Thai population shows polymorphism of the KIR genes and the diversities of KIR genes in Thai differed from other populations. These data might be of benefit to future studies of the KIR gene and its association with diseases.