Publication: In vitro blood schizonticidal activity of sera containing mefloquine-quinine against Plasmodium falciparum
Issued Date
1997-01-01
Resource Type
ISSN
13602276
Other identifier(s)
2-s2.0-0031053831
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tropical Medicine and International Health. Vol.2, No.2 (1997), 159-164
Suggested Citation
P. Tan-ariya, K. Na-Bangchang, R. Ubalee, S. Boutes, S. Riengchainam, J. Karbwang In vitro blood schizonticidal activity of sera containing mefloquine-quinine against Plasmodium falciparum. Tropical Medicine and International Health. Vol.2, No.2 (1997), 159-164. doi:10.1046/j.1365-3156.1997.d01-243.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17978
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
In vitro blood schizonticidal activity of sera containing mefloquine-quinine against Plasmodium falciparum
Other Contributor(s)
Abstract
Serum samples collected at intervals from healthy volunteers, after the administration of 3 drug regimens (quinine (QN) 600 mg, mefloquine (MQ) 750 mg, and MQ 750 mg plus QN 600 mg) were investigated for their blood schizonticidal activities against K(I) strain Plasmodium falciparum in vitro. Superiority of activity was shown in the sera collected after the combination regimen. In the diluted sera of the QN regimen, a complete inhibitory effect was observed for only 24 hours, whereas the effect was sustained for 72 hours in the sera collected after MQ in either regimen (MQ alone or MQ/QN). The pattern of minimum inhibitory concentrations (MICs) of QNEq of the sera from QN alone was constant throughout a 24-hour period, with significantly higher concentrations than that from the combination regimen (118-150 vs 21.25-73.5 μg/l). In sera collected after the combination regimen, however, the MIC gradually decreased from 0.5 until 2.5 and 4 h, and thereafter gradually returned to the same levels again during a period of 6-24 hours. The MICs of MQEq when given as MQ alone or in combination appeared constant, with a significantly higher value in the former regimen (24.4-26.8 vs 17-19.2 μg/l).