Publication: Impaired Blood Clearance of Bacteria and Phagocytic Activity in Vitamin A-Deficient Rats (41999)
Issued Date
1985-01-01
Resource Type
ISSN
15353699
00379727
00379727
Other identifier(s)
2-s2.0-0021944247
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the Society for Experimental Biology and Medicine. Vol.178, No.2 (1985), 204-208
Suggested Citation
M. Ongsakul, S. Sirisinha, A. J. Lamb Impaired Blood Clearance of Bacteria and Phagocytic Activity in Vitamin A-Deficient Rats (41999). Proceedings of the Society for Experimental Biology and Medicine. Vol.178, No.2 (1985), 204-208. doi:10.3181/00379727-178-41999 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30746
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Impaired Blood Clearance of Bacteria and Phagocytic Activity in Vitamin A-Deficient Rats (41999)
Author(s)
Other Contributor(s)
Abstract
The effect of vitamin A deficiency on the functional integrity of the reticuloendothelial system and the phagocytic capacity of circulating polymorphonuclear leukocytes was evaluated in retinoate-cycled vitamin A-deficient rats under conditions such that secondary dietary imbalances were eliminated. Kinetics of blood clearance of 2 × 107Escherichia coli injected intravenously was depressed within 8 days of the withdrawal of retinoic acid; all animals were profoundly affected by Day 12 of deficiency. In vitro, the phagocytic activity of polymorphonuclear leukocytes was similarly affected; by Day 12 of deficiency, phagocytic capacity in all deficient animals was less than 40% of the appropriate control values (P < 0.01). Animals rendered vitamin A deficient by this procedure also displayed marked susceptibility to endogenous bacterial infection, as judged from the proportion of deficient rats that spontaneously developed bacteremia during the later stages of deficiency. These data together demonstrate unequivocally that reticuloendothelial and polymorphonuclear leukocytic functions are impaired in vitamin A deficiency in the absence of other dietary imbalances. © 1985, SAGE Publications. All rights reserved.