Publication: Evolution of MRSA during hospital transmission and intercontinental spread
Issued Date
2010-01-22
Resource Type
ISSN
10959203
00368075
00368075
Other identifier(s)
2-s2.0-75649084906
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Mahidol University
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SCOPUS
Bibliographic Citation
Science. Vol.327, No.5964 (2010), 469-474
Suggested Citation
Simon R. Harris, Edward J. Feil, Matthew T.G. Holden, Michael A. Quail, Emma K. Nickerson, Narisara Chantratita, Susana Gardete, Ana Tavares, Nick Day, Jodi A. Lindsay, Jonathan D. Edgeworth, Hermínia De Lencastre, Julian Parkhill, Sharon J. Peacock, Stephen D. Bentley Evolution of MRSA during hospital transmission and intercontinental spread. Science. Vol.327, No.5964 (2010), 469-474. doi:10.1126/science.1182395 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29987
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Title
Evolution of MRSA during hospital transmission and intercontinental spread
Other Contributor(s)
Wellcome Trust Sanger Institute
University of Bath
Mahidol University
University of Cambridge
Instituto de Tecnologia Quimica e Biologica - Univesidade Nova de Lisboa
Rockefeller University
Nuffield Department of Clinical Medicine
St George's University of London
King's College London
Guy's and St Thomas' NHS Foundation Trust
University of Bath
Mahidol University
University of Cambridge
Instituto de Tecnologia Quimica e Biologica - Univesidade Nova de Lisboa
Rockefeller University
Nuffield Department of Clinical Medicine
St George's University of London
King's College London
Guy's and St Thomas' NHS Foundation Trust
Abstract
Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a highthroughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.