Publication: The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
Issued Date
2015-08-03
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ISSN
1178203X
11766336
11766336
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2-s2.0-84939444736
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Mahidol University
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SCOPUS
Bibliographic Citation
Therapeutics and Clinical Risk Management. Vol.11, (2015), 1143-1147
Suggested Citation
Yuwares Sittichanbuncha, Pungkava Sricharoen, Panvilai Tangkulpanich, Kittisak Sawanyawisuth The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients. Therapeutics and Clinical Risk Management. Vol.11, (2015), 1143-1147. doi:10.2147/TCRM.S85671 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35698
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Title
The appropriate troponin T level associated with coronary occlusions in chronic kidney disease patients
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Abstract
© 2015, Sittichanbuncha et al. Background: High-sensitivity troponin T (HS Trop T) plays an important role as a diagnostic marker for acute coronary syndrome. It is also related to cardiovascular outcomes. HS Trop T levels may be varied in individuals with renal dysfunction. This study aimed to find the appropriate HS Trop T cutoff points in chronic kidney disease (CKD) patients who had coronary artery occlusion. Patients and methods: The study was conducted at the Emergency Department, Ramathibodi Hospital, Mahidol University, Thailand. CKD patients stage 3–5 who had HS Trop T levels after 2 hours of chest pain and had coronary angiographic results were enrolled. Patients were divided into two groups: those who had significant occlusion of more than 70% of a coronary artery as the coronary artery disease (CAD) group and the non-CAD group. Results: In total, 210 patients met the study criteria. There were 132 patients (62.86%) who had significant stenosis of coronary arteries by coronary angiograms. The average age (standard deviation) of all patients was 71.02 (9.49) years. HS Trop T levels were significantly higher in all CKD patients with CAD than the non-CAD group (0.4973 versus 0.0384 ng/mL). Sex and HS Trop T levels were significantly associated with CAD by multivariate logistic regression analysis. The HS Trop T level of 0.041 ng/mL gave sensitivity and specificity of 65.91% and 75.65%, respectively, for CAD. Conclusion: The HS Trop T level of 0.041 ng/mL provided diagnostic properties for established coronary artery occlusion in CKD patients.