Publication: Genotype C of hepatitis B virus can be classified into at least two subgroups
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Issued Date
2004-02-01
Resource Type
ISSN
00221317
Other identifier(s)
2-s2.0-1342332028
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of General Virology. Vol.85, No.2 (2004), 283-292
Suggested Citation
Tran Thien Tuan Huy, Hiroshi Ushijima, Vo Xuan Quang, Khin Maung Win, Pairoj Leungrojanakul, Kaoru Kikuchi, Tetsutaro Sata, Kenji Abe Genotype C of hepatitis B virus can be classified into at least two subgroups. Journal of General Virology. Vol.85, No.2 (2004), 283-292. doi:10.1099/vir.0.19633-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21405
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Title
Genotype C of hepatitis B virus can be classified into at least two subgroups
Abstract
A genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis of the pre-S1/pre-S2 genes revealed two major groups within genotype C: one for isolates from southeast Asia including Vietnam, Myanmar and Thailand (named HBV/C1) and the other for isolates from Far East Asia including Japan, Korea and China (named HBV/C2). This finding was confirmed by phylogenetic analysis based on the full-length sequence of 32 HBV genotype C isolates, including 22 from database entries. Two isolates from Okinawa, the island off the southern end of Japan, formed a different branch. Specific amino acid sequence changes were identified in the large S protein (amino acids 51, 54, 60, 62 and 73) and P protein (amino acids 231, 233, 236, 248, 252 and 304). Our results indicate that genotype C of HBV can be classified into at least two subgroups. © 2004 SGM.