Publication: Allogeneic bone marrow transplantation in an osteopetrosis patient: First report in Thailand
Issued Date
1998-12-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-0032455355
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.16, No.4 (1998), 193-198
Suggested Citation
Suradej Hongeng, Samart Pakakasama, Ampaiwan Chuansumrit, Busaba Rerkamnuaychoke, Prawat Nitiyanunt, Umaporn Suthutvoravut, Artit Ungkanont, Phongjan Hathirat Allogeneic bone marrow transplantation in an osteopetrosis patient: First report in Thailand. Asian Pacific Journal of Allergy and Immunology. Vol.16, No.4 (1998), 193-198. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18449
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Allogeneic bone marrow transplantation in an osteopetrosis patient: First report in Thailand
Other Contributor(s)
Abstract
We described the successful allogeneic matched sibling bone marrow transplantation (BMT) in a 5-year-old Thai boy in whom osteopetrosis was diagnosed on the basis of anemia, thrombocytopenia, leukoerythroblastosis, sclerotic bone, hepatosplenomegaly, and visual deficit from an encroachment of cranial nerve foramina. The preparative regimen included 4 days of busulfan 4mg/kg/day, and 4 days of cyclophosphamide 50 mg/kg/day. Complete hematopoietic engraftment and no evidence of graft versus host disease were shown after BMT. Complete hematologic findings were corrected. His hematopoietic chimerism was changed to that of his donor. Post BMT, he has no hepatosplenomegaly. His bone radiographic findings revealed normal after BMT. Bone marrow biopsy showed normalized bone and bone marrow matrix. However, his vision remained impaired. We believe that this is the first case of successful bone marrow transplantation in an osteopetrosis patient in Thailand.
