Publication: The immune response against flaviviruses
Issued Date
2018-11-01
Resource Type
ISSN
15292916
15292908
15292908
Other identifier(s)
2-s2.0-85055206461
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Immunology. Vol.19, No.11 (2018), 1189-1198
Suggested Citation
Jose Luis Slon Campos, Juthathip Mongkolsapaya, Gavin R. Screaton The immune response against flaviviruses. Nature Immunology. Vol.19, No.11 (2018), 1189-1198. doi:10.1038/s41590-018-0210-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45947
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Title
The immune response against flaviviruses
Abstract
© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Arthropod-borne flaviviruses are important human pathogens that cause a diverse range of clinical conditions, including severe hemorrhagic syndromes, neurological complications and congenital malformations. Consequently, there is an urgent need to develop safe and effective vaccines, a process requiring better understanding of the immunological mechanisms involved during infection. Decades of research suggest a paradoxical role of the immune response against flaviviruses: although the immune response is crucial for the control, clearance and prevention of infection, poor clinical outcomes are commonly associated with virus-specific immunity and immunopathogenesis. This relationship is further complicated by the high homology among viruses and the implication of cross-reactive immune responses in protection and pathogenesis. This Review examines the dual role of the adaptive immune response against flaviviruses, particularly emphasizing the most recent findings regarding cross-reactive T cell and antibody responses, and the effects that these concepts have on vaccine-development endeavors.