Publication: Preparation of surfactant-free nanoparticles of methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide-co-e-caprolactone)
Issued Date
2009-02-01
Resource Type
ISSN
1061933X
Other identifier(s)
2-s2.0-66849114872
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Colloid Journal. Vol.71, No.1 (2009), 18-21
Suggested Citation
Y. Baimark, M. Srisa-Ard, J. Threeprom, P. Phinyocheep, S. Kittipoom Preparation of surfactant-free nanoparticles of methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide-co-e-caprolactone). Colloid Journal. Vol.71, No.1 (2009), 18-21. doi:10.1134/S1061933X09010025 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27387
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Title
Preparation of surfactant-free nanoparticles of methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide-co-e-caprolactone)
Abstract
Surfactant-free nanoparticles of methoxy poly(ethylene glycol)-b-poly(D,L- lactide-co-glycolide-co-ε-caprolactone) diblock copolymers (MPEG-b-PDLLGCL) with different DLL:G:CL ratios were prepared by modified-spontaneous emulsification solvent diffusion method. Sizes of resulted colloidal nanoparticles obtained from light-scattering analysis were in the range of 121-132 nm with narrow size distribution. The nanoparticle sizes depended on the composition of the PDLLGCL block. Scanning electron microscopy demonstrated that the nanoparticles were aggregated after drying process, suggested they were soft nanoparticles. However, their initial aggregates can be observed and it was shown that the nanoparticles have spherical shape with smooth surface. © 2009 Pleiades Publishing, Ltd.